MDM2 Promotes Proteasomal Degradation of p21(Waf1) via a Conformation Change

MDM2 plays a major role in cancer development and progression via both p53-dependent and -independent functions. One of its p53-independent functions is the induction of the ubiquitin-independent proteasomal degradation of p21(Waf1). The present study was designed to characterize the mechanism(s) by...

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Bibliographic Details
Main Authors: Xu, Hongxia, Zhang, Zhuo, Li, Mao, Zhang, Ruiwen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881766/
https://ncbi.nlm.nih.gov/pubmed/20308078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059568
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