Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1

Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized and demonstrated that small engineered antibodies can target highly conser...

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Detalhes bibliográficos
Main Authors: Zhang, Mei-Yun, Borges, Andrew Rosa, Ptak, Roger G, Wang, Yanping, Dimitrov, Antony S, Alam, S. Munir, Wieczorek, Lindsay, Bouma, Peter, Fouts, Timothy, Jiang, Shibo, Polonis, Victoria R, Haynes, Barton F, Quinnan, Gerald V, Montefiori, David C, Dimitrov, Dimiter S
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881253/
https://ncbi.nlm.nih.gov/pubmed/20305395
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