Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation.

We have characterized the molecular defect causing androgen resistance in two 46,XY siblings with complete testicular feminization. Although binding studies in genital skin fibroblasts showed a reduced Bmax, an increased dissociation rate of ligand, and an 8S peak of dihydrotestosterone binding on s...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Zoppi, S, Wilson, C M, Harbison, M D, Griffin, J E, Wilson, J D, McPhaul, M J, Marcelli, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8450040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116269
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