Loading...

Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase is being pursued with the assistance of free energy perturbation (FEP) calculations to predict relative free energies of binding. Extension of azole-containing inhibitors into an ‘eastern’ channel between Phe227 and Pro236 has led to...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Leung, Cheryl S., Zeevaart, Jacob G., Domaoal, Robert A., Bollini, Mariela, Thakur, Vinay V., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880392/
https://ncbi.nlm.nih.gov/pubmed/20304641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.03.006
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!