Treatment of Heart Failure by a Methanocarba Derivative of Adenosine Monophosphate: Implication for a Role of Cardiac Purinergic P2X Receptors

Evidence is accumulating to support a potentially important role for purinergic (P2X) receptors in heart failure (HF). We tested the hypothesis that a hydrolysis-resistant nucleotide analog with agonist activity at myocardial P2X receptors (P2XRs) improves the systolic HF phenotype in mouse and dog...

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Detalhes bibliográficos
Main Authors: Zhou, Si-Yuan, Mamdani, Mohammed, Qanud, Khaled, Shen, Jian-Bing, Pappano, Achilles J., Kumar, T. Santhosh, Jacobson, Kenneth A., Hintze, Thomas, Recchia, Fabio A., Liang, Bruce T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879931/
https://ncbi.nlm.nih.gov/pubmed/20200116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.164376
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