5’-Phosphate and 5’-Phosphonate Ester Derivatives of (N)-Methanocarba Adenosine with in Vivo Cardioprotective Activity

Activation of a cardiac myocyte P2X4 receptor protects in heart failure. 5’-Phosphonate and 5’-phosphate analogues of AMP containing a (N)-methanocarba (bicyclo[3.1.0]hexane) system could protect from heart failure by potentially activating this cardioprotective channel. Phosphoesters and phosphonod...

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Detalhes bibliográficos
Main Authors: Kumar, T. Santhosh, Yang, Tiehong, Mishra, Shilpi, Cronin, Chunxia, Charkaborty, Saibal, Shen, Jian-Bing, Liang, Bruce T., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574217/
https://ncbi.nlm.nih.gov/pubmed/23286881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301372c
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