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Covalent Modification of Thr302 in Cytochrome P450 2B1 by the Mechanism-Based Inactivator 4-tert-Butylphenylacetylene

The mechanism of inactivation of cytochrome P450 2B1 (CYP2B1) by 4-tert-butylphenylacetylene (BPA) has been characterized previously to be caused by the covalent binding of a reactive intermediate to the apoprotein rather than heme destruction (J Pharmacol Exp Ther 331:392–403, 2009). The identifica...

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Bibliografiske detaljer
Main Authors: Lin, Hsia-lien, Zhang, Haoming, Jushchyshyn, Monica, Hollenberg, Paul F.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879930/
https://ncbi.nlm.nih.gov/pubmed/20200115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.164350
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