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Acetaminophen Elimination Half-Life in Humans Is Unaffected by Short-Term Consumption of Sulfur Amino Acid-Free Diet
Sulfation and glutathione (GSH) conjugation are important pathways for elimination of acetaminophen (APAP). Previous studies in rodents show that limitation of dietary sulfur amino acids (SAAs) reduces biosynthesis of 3′-phosphoadenosine-5′-phosphosulfate, the precursor for sulfation, and GSH, the p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879925/ https://ncbi.nlm.nih.gov/pubmed/20207720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166439 |
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