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The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody forming cell and germinal center checkpoints
We have described a line of V(H) “knockin” mice termed HKIR in which the transgenic Igh locus partially encodes “dual reactive” anti-chromatin and anti-arsonate (Ars) BCRs. HKIR B cells termed canonical, expressing a particular Vκ light chain, evade central tolerance by down regulating BCR levels. C...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879885/ https://ncbi.nlm.nih.gov/pubmed/19828626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804215 |
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