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Use-Dependent Block of Cardiac Late Na(+) Current by Ranolazine

BACKGROUND: Ranolazine is an antianginal drug that inhibits the cardiac late Na(+) current (I(Na)). The selectivity of ranolazine to block late I(Na) relative to peak I(Na) at rapid heart rates has not been determined, but is potentially important to drug efficacy and safety. OBJECTIVE: To quantify...

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Bibliografiske detaljer
Main Authors: Rajamani, Sridharan, El-Bizri, Nesrine, Shryock, John C., Makielski, Jonathan C., Belardinelli, Luiz
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879577/
https://ncbi.nlm.nih.gov/pubmed/19879541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2009.07.042
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