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Use-Dependent Block of Cardiac Late Na(+) Current by Ranolazine
BACKGROUND: Ranolazine is an antianginal drug that inhibits the cardiac late Na(+) current (I(Na)). The selectivity of ranolazine to block late I(Na) relative to peak I(Na) at rapid heart rates has not been determined, but is potentially important to drug efficacy and safety. OBJECTIVE: To quantify...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879577/ https://ncbi.nlm.nih.gov/pubmed/19879541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2009.07.042 |
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