Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries

Microarray-based enrichment of selected genomic loci is a powerful method for genome complexity reduction for next-generation sequencing. Since the vast majority of exons in vertebrate genomes are smaller than 150 nt, we explored the use of short fragment libraries (85–110 bp) to achieve higher enri...

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Autores principales: Mokry, Michal, Feitsma, Harma, Nijman, Isaac J., de Bruijn, Ewart, van der Zaag, Pieter J., Guryev, Victor, Cuppen, Edwin
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
Methods Online
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879533/
https://ncbi.nlm.nih.gov/pubmed/20164091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq072
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