Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity

POLN is a nuclear A-family DNA polymerase encoded in vertebrate genomes. POLN has unusual fidelity and DNA lesion bypass properties, including strong strand displacement activity, low fidelity favoring incorporation of T for template G and accurate translesion synthesis past a 5S-thymine glycol (5S-...

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Hlavní autoři: Takata, Kei-ichi, Arana, Mercedes E., Seki, Mineaki, Kunkel, Thomas A., Wood, Richard D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879524/
https://ncbi.nlm.nih.gov/pubmed/20144948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq048
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