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Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor

The sweet protein brazzein activates the human sweet receptor, a heterodimeric G-protein coupled receptor (GPCR) composed of subunits T1R2 and T1R3. In order to elucidate the key amino acid(s) responsible for this interaction, we mutated residues in brazzein and each of the two subunits of the recep...

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書誌詳細
主要な著者: Assadi-Porter, Fariba M., Maillet, Emeline L., Radek, James T., Quijada, Jeniffer, Markley, John L., Max, Marianna
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879441/
https://ncbi.nlm.nih.gov/pubmed/20302879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.017
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