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Intracellular Accumulation of Amyloid-Beta – A Predictor for Synaptic Dysfunction and Neuron Loss in Alzheimer's Disease

Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear. During the last years there is growing evidence that early intraneuronal accumulation of Aβ peptides is one of th...

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Autori principali: Bayer, Thomas A., Wirths, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Research Foundation 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879032/
https://ncbi.nlm.nih.gov/pubmed/20552046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2010.00008
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