The Human COP9 Signalosome Protects Ubiquitin-conjugating Enzyme 3 (UBC3/Cdc34) from β-Transducin Repeat-containing Protein (βTrCP)-mediated Degradation

The COP9 signalosome (CSN) is an essential multisubunit complex that regulates the activity of cullin-RING ubiquitin ligases by removing the ubiquitin-like peptide NEDD8 from cullins. Here, we demonstrate that the CSN can affect other components of the ubiquitination cascade. Down-regulation of huma...

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Autors principals: Fernandez-Sanchez, Maria Elena, Sechet, Emmanuel, Margottin-Goguet, Florence, Rogge, Lars, Bianchi, Elisabetta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878502/
https://ncbi.nlm.nih.gov/pubmed/20378537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076661
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