Transforming Growth Factor β Facilitates β-TrCP-Mediated Degradation of Cdc25A in a Smad3-Dependent Manner

Ubiquitin-dependent degradation of Cdc25A is a major mechanism for damage-induced S-phase checkpoint. Two ubiquitin ligases, the Skp1-cullin-β-TrCP (SCF(β-TrCP)) complex and the anaphase-promoting complex (APC(Cdh1)), are involved in Cdc25A degradation. Here we demonstrate that the transforming grow...

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Detalhes bibliográficos
Main Authors: Ray, Dipankar, Terao, Yasuhisa, Nimbalkar, Dipali, Chu, Li-Hao, Donzelli, Maddalena, Tsutsui, Tateki, Zou, Xianghong, Ghosh, Asish K., Varga, John, Draetta, Giulio F., Kiyokawa, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069597/
https://ncbi.nlm.nih.gov/pubmed/15798217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3338-3347.2005
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