Fluorescence-Tracking of Activation Gating in Human ERG Channels Reveals Rapid S4 Movement and Slow Pore Opening

BACKGROUND: hERG channels are physiologically important ion channels which mediate cardiac repolarization as a result of their unusual gating properties. These are very slow activation compared with other mammalian voltage-gated potassium channels, and extremely rapid inactivation. The mechanism of...

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Bibliographic Details
Main Authors: Es-Salah-Lamoureux, Zeineb, Fougere, Robert, Xiong, Ping Yu, Robertson, Gail A., Fedida, David
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878317/
https://ncbi.nlm.nih.gov/pubmed/20526358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010876
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