RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53

Although it has been shown that the gastric tumor suppressor RUNX3 has a growth inhibitory activity, the precise molecular mechanisms behind RUNX3-mediated tumor suppression remained unclear. In this study, we found that RUNX3 is closely involved in DNA damage-dependent phosphorylation of tumor supp...

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Bibliografiske detaljer
Main Authors: Yamada, Chizu, Ozaki, Toshinori, Ando, Kiyohiro, Suenaga, Yusuke, Inoue, Ken-ichi, Ito, Yoshiaki, Okoshi, Rintaro, Kageyama, Hajime, Kimura, Hideki, Miyazaki, Masaru, Nakagawara, Akira
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878082/
https://ncbi.nlm.nih.gov/pubmed/20353948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055525
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