Inhibitory Role of Plk1 in the Regulation of p73-dependent Apoptosis through Physical Interaction and Phosphorylation

In response to DNA damage, p73 plays a critical role in cell fate determination. In this study, we have found that Plk1 (polo-like kinase 1) associates with p73, phosphorylates p73 at Thr-27, and thereby inhibits its pro-apoptotic activity. During cisplatin-mediated apoptosis in COS7 cells in which...

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Detalhes bibliográficos
Main Authors: Koida, Nami, Ozaki, Toshinori, Yamamoto, Hideki, Ono, Sayaka, Koda, Tadayuki, Ando, Kiyohiro, Okoshi, Rintaro, Kamijo, Takehiko, Omura, Ken, Nakagawara, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2417181/
https://ncbi.nlm.nih.gov/pubmed/18174154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710608200
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