Loading...

Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M(2) Isozyme and Promote Cellular Growth and Polyploidy

This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cell...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Gupta, Vibhor, Kalaiarasan, Ponnusamy, Faheem, Mohammad, Singh, Nishant, Iqbal, Mohammad Askandar, Bamezai, Rameshwar N. K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878009/
https://ncbi.nlm.nih.gov/pubmed/20304929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065029
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!