Differential Behavior of Missense Mutations in the Intersubunit Contact Domain of the Human Pyruvate Kinase M(2) Isozyme

In this study, we attempted to understand the mechanism of regulation of the activity and allosteric behavior of the pyruvate kinase M(2) enzyme and two of its missense mutations, H391Y and K422R, found in cells from Bloom syndrome patients, prone to develop cancer. Results show that despite the pre...

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Bibliographic Details
Main Authors:	Akhtar, Kamal, Gupta, Vibhor, Koul, Anita, Alam, Neelima, Bhat, Rajiv, Bamezai, Rameshwar N. K.
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2009
Subjects:	Enzyme Catalysis and Regulation
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2673266/ https://ncbi.nlm.nih.gov/pubmed/19265196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808761200
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Differential Behavior of Missense Mutations in the Intersubunit Contact Domain of the Human Pyruvate Kinase M(2) Isozyme

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