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Differential Behavior of Missense Mutations in the Intersubunit Contact Domain of the Human Pyruvate Kinase M(2) Isozyme
In this study, we attempted to understand the mechanism of regulation of the activity and allosteric behavior of the pyruvate kinase M(2) enzyme and two of its missense mutations, H391Y and K422R, found in cells from Bloom syndrome patients, prone to develop cancer. Results show that despite the pre...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Biochemistry and Molecular Biology
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2673266/ https://ncbi.nlm.nih.gov/pubmed/19265196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808761200 |
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