Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M(2) Isozyme and Promote Cellular Growth and Polyploidy

This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cell...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gupta, Vibhor, Kalaiarasan, Ponnusamy, Faheem, Mohammad, Singh, Nishant, Iqbal, Mohammad Askandar, Bamezai, Rameshwar N. K.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878009/
https://ncbi.nlm.nih.gov/pubmed/20304929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065029
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires