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Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M(2) Isozyme and Promote Cellular Growth and Polyploidy
This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cell...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2878009/ https://ncbi.nlm.nih.gov/pubmed/20304929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065029 |
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