Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M(2) Isozyme and Promote Cellular Growth and Polyploidy

This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cell...

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Detalhes bibliográficos
Main Authors: Gupta, Vibhor, Kalaiarasan, Ponnusamy, Faheem, Mohammad, Singh, Nishant, Iqbal, Mohammad Askandar, Bamezai, Rameshwar N. K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878009/
https://ncbi.nlm.nih.gov/pubmed/20304929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065029
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