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Dominant Negative Mutations Affect Oligomerization of Human Pyruvate Kinase M(2) Isozyme and Promote Cellular Growth and Polyploidy

This study was designed to understand the mechanism and functional implication of the two heterozygous mutations (H391Y and K422R) of human pyruvate kinase M2 isozyme (PKM(2)) observed earlier in a Bloom syndrome background. The co-expression of homotetrameric wild type and mutant PKM(2) in the cell...

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Détails bibliographiques
Auteurs principaux: Gupta, Vibhor, Kalaiarasan, Ponnusamy, Faheem, Mohammad, Singh, Nishant, Iqbal, Mohammad Askandar, Bamezai, Rameshwar N. K.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878009/
https://ncbi.nlm.nih.gov/pubmed/20304929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065029
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