Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization of serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic asthma, one limitation of this approach is its lack of effect on IgE production. H...

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Autores principales: Brightbill, Hans D., Jeet, Surinder, Lin, Zhonghua, Yan, Donghong, Zhou, Meijuan, Tan, Martha, Nguyen, Allen, Yeh, Sherry, Delarosa, Donnie, Leong, Steven R., Wong, Terence, Chen, Yvonne, Ultsch, Mark, Luis, Elizabeth, Ramani, Sree Ranjani, Jackman, Janet, Gonzalez, Lino, Dennis, Mark S., Chuntharapai, Anan, DeForge, Laura, Meng, Y. Gloria, Xu, Min, Eigenbrot, Charles, Lee, Wyne P., Refino, Canio J., Balazs, Mercedesz, Wu, Lawren C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877936/
https://ncbi.nlm.nih.gov/pubmed/20458139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40141
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