Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

Antiapoptotic BCL2 family members have been implicated in the pathogenesis of acute myelogenous leukemia (AML), but the functional significance and relative importance of individual proteins (e.g., BCL2, BCL-XL, and myeloid cell leukemia 1 [MCL1]) remain poorly understood. Here, we examined the expr...

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Detalhes bibliográficos
Main Authors: Xiang, Zhifu, Luo, Hui, Payton, Jacqueline E., Cain, Jennifer, Ley, Timothy J., Opferman, Joseph T., Tomasson, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877934/
https://ncbi.nlm.nih.gov/pubmed/20484815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39964
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