Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

Somatic mutations in JAK2 are frequently found in myeloproliferative diseases, and gain-of-function JAK3 alleles have been identified in M7 acute myeloid leukemia (AML), but a role for JAK1 in AML has not been described. We screened the entire coding region of JAK1 by total exonic resequencing of bo...

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Main Authors: Xiang, Zhifu, Zhao, Yu, Mitaksov, Vesselin, Fremont, Daved H., Kasai, Yumi, Molitoris, AnnaLynn, Ries, Rhonda E., Miner, Tracie L., McLellan, Michael D., DiPersio, John F., Link, Daniel C., Payton, Jacqueline E., Graubert, Timothy A., Watson, Mark, Shannon, William, Heath, Sharon E., Nagarajan, Rakesh, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Tomasson, Michael H.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343608/
https://ncbi.nlm.nih.gov/pubmed/18160671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-090308
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