TNF-α and IL-1β increase Ca(2+) leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

Sepsis is associated with ventricular dysfunction and increased incidence of atrial and ventricular arrhythmia however the underlying pro-arrhythmic mechanisms are unknown. Serum levels of tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are elevated during sepsis and affect Ca(2+) regula...

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Main Authors: Duncan, David J., Yang, Zhaokang, Hopkins, Philip M., Steele, Derek S., Harrison, Simon M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2010
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877880/
https://ncbi.nlm.nih.gov/pubmed/20227109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2010.02.002
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