Phylogenetic Analysis of Population-Based and Deep Sequencing Data to Identify Coevolving Sites in the nef Gene of HIV-1

Rapidly evolving viruses such as HIV-1 display extensive sequence variation in response to host-specific selection, while simultaneously maintaining functions that are critical to replication and infectivity. This apparent conflict between diversifying and purifying selection may be resolved by an a...

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Detalhes bibliográficos
Main Authors: Poon, Art F.Y., Swenson, Luke C., Dong, Winnie W.Y., Deng, Wenjie, Kosakovsky Pond, Sergei L., Brumme, Zabrina L., Mullins, James I., Richman, Douglas D., Harrigan, P. Richard, Frost, Simon D.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877536/
https://ncbi.nlm.nih.gov/pubmed/19955476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msp289
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