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A Maximum Likelihood Method for Detecting Directional Evolution in Protein Sequences and Its Application to Influenza A Virus
We develop a model-based phylogenetic maximum likelihood test for evidence of preferential substitution toward a given residue at individual positions of a protein alignment—directional evolution of protein sequences (DEPS). DEPS can identify both the target residue and sites evolving toward it, hel...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515872/ https://ncbi.nlm.nih.gov/pubmed/18511426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msn123 |
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