A Maximum Likelihood Method for Detecting Directional Evolution in Protein Sequences and Its Application to Influenza A Virus

We develop a model-based phylogenetic maximum likelihood test for evidence of preferential substitution toward a given residue at individual positions of a protein alignment—directional evolution of protein sequences (DEPS). DEPS can identify both the target residue and sites evolving toward it, hel...

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Detaylı Bibliyografya
Asıl Yazarlar: Kosakovsky Pond, Sergei L., Poon, Art F.Y., Leigh Brown, Andrew J., Frost, Simon D.W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2008
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515872/
https://ncbi.nlm.nih.gov/pubmed/18511426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msn123
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