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Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF, Sec2p
Sec2p is the guanine nucleotide exchange factor (GEF) that activates the Rab GTPase Sec4p on secretory vesicles. Sec2p also binds a Rab acting earlier in the secretory pathway, Ypt32p-GTP, forming a RabGEF cascade. Ypt32p and the Sec4p effector Sec15p (a component of the exocyst complex) compete for...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2877039/ https://ncbi.nlm.nih.gov/pubmed/20493815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.03.016 |
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