AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX

Programmed necrosis induced by DNA alkylating agents, such as MNNG, is a caspase-independent mode of cell death mediated by apoptosis-inducing factor (AIF). After poly(ADP-ribose) polymerase 1, calpain, and Bax activation, AIF moves from the mitochondria to the nucleus where it induces chromatinolys...

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Main Authors: Artus, Cédric, Boujrad, Hanan, Bouharrour, Aïda, Brunelle, Marie-Noëlle, Hoos, Sylviane, Yuste, Victor J, Lenormand, Pascal, Rousselle, Jean-Claude, Namane, Abdelkader, England, Patrick, Lorenzo, Hans K, Susin, Santos A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876946/
https://ncbi.nlm.nih.gov/pubmed/20360685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.43
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