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AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
Programmed necrosis induced by DNA alkylating agents, such as MNNG, is a caspase-independent mode of cell death mediated by apoptosis-inducing factor (AIF). After poly(ADP-ribose) polymerase 1, calpain, and Bax activation, AIF moves from the mitochondria to the nucleus where it induces chromatinolys...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876946/ https://ncbi.nlm.nih.gov/pubmed/20360685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.43 |
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