AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation

The alkylating DNA-damage agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induces a form of caspase-independent necroptosis implicating the mitochondrial flavoprotein apoptosis-inducing factor (AIF). Following the activation of PARP-1 (poly(ADP-ribose) polymerase-1), calpains, BID (BH3 interacting...

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Autors principals: Baritaud, M, Cabon, L, Delavallée, L, Galán-Malo, P, Gilles, M-E, Brunelle-Navas, M-N, Susin, S A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461360/
https://ncbi.nlm.nih.gov/pubmed/22972376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.120
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