Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating

Voltage-gated proton channels are strongly inhibited by Zn(2+), which binds to His residues. However, in a molecular model, the two externally accessible His are too far apart to coordinate Zn(2+). We hypothesize that high-affinity Zn(2+) binding occurs at the dimer interface between pairs of His re...

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Autores principales: Musset, Boris, Smith, Susan M E, Rajan, Sindhu, Cherny, Vladimir V, Sujai, Sukrutha, Morgan, Deri, DeCoursey, Thomas E
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2010
Materias:
Molecular and Cellular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876801/
https://ncbi.nlm.nih.gov/pubmed/20231140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.188318
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