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Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel
The voltage-gated proton channel (H(V)1) is a voltage sensor that also conducts protons. The singular ability of protons to penetrate proteins complicates distinguishing closed and open channels. When we replaced valine with histidine at position 116 in the external vestibule of hH(V)1, current was...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7537347/ https://ncbi.nlm.nih.gov/pubmed/32902579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012664 |
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