Engineered high-affinity zinc binding site reveals gating configurations of a human proton channel

The voltage-gated proton channel (H(V)1) is a voltage sensor that also conducts protons. The singular ability of protons to penetrate proteins complicates distinguishing closed and open channels. When we replaced valine with histidine at position 116 in the external vestibule of hH(V)1, current was...

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Bibliographic Details
Published in:J Gen Physiol
Main Authors: Cherny, Vladimir V., Musset, Boris, Morgan, Deri, Thomas, Sarah, Smith, Susan M.E., DeCoursey, Thomas E.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537347/
https://ncbi.nlm.nih.gov/pubmed/32902579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012664
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