Efficient Generation of Mucosal and Systemic Antigen-Specific CD8(+) T-Cell Responses following Pulmonary DNA Immunization

Although mucosal CD8(+) T-cell responses are important in combating mucosal infections, the generation of such immune responses by vaccination remains problematic. In the present study, we evaluated the ability of plasmid DNA to induce local and systemic antigen-specific CD8(+) T-cell responses afte...

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Main Authors: Bivas-Benita, Maytal, Bar, Liat, Gillard, Geoffrey O., Kaufman, David R., Simmons, Nathaniel L., Hovav, Avi-Hai, Letvin, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876582/
https://ncbi.nlm.nih.gov/pubmed/20335249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02202-09
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