Cellular Pharmacodynamics of the Novel Biaryloxazolidinone Radezolid: Studies with Infected Phagocytic and Nonphagocytic cells, Using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila

Radezolid is a novel biaryloxazolidinone in clinical development which shows improved activity, including against linezolid-resistant strains. In a companion paper (29), we showed that radezolid accumulates about 11-fold in phagocytic cells, with ∼60% of the drug localized in the cytosol and ∼40% in...

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Detalhes bibliográficos
Main Authors: Lemaire, Sandrine, Kosowska-Shick, Klaudia, Appelbaum, Peter C., Verween, Gunther, Tulkens, Paul M., Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876393/
https://ncbi.nlm.nih.gov/pubmed/20385852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01724-09
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