Azole Resistance Profile of Amino Acid Changes in Aspergillus fumigatus CYP51A Based on Protein Homology Modeling

Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus is associated with amino acid substitutions in the cyp51A gene. To obtain insight into azole resistance mutations, the cyp51A gene of 130 resistant and 76 susceptible A. fumigatus isolates was sequenced. Out...

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Detaylı Bibliyografya
Asıl Yazarlar: Snelders, Eveline, Karawajczyk, Anna, Schaftenaar, Gijs, Verweij, Paul E., Melchers, Willem J. G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2010
Konular:
Mechanisms of Resistance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876375/
https://ncbi.nlm.nih.gov/pubmed/20385860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01599-09
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