Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence

Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. The first two isolates (1 and 2) were susceptible to antifungal azoles, but increased itraconazole, voriconazole and pos...

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Main Authors: Arendrup, Maiken Cavling, Mavridou, Eleftheria, Mortensen, Klaus Leth, Snelders, Eveline, Frimodt-Møller, Niels, Khan, Humara, Melchers, Willem J. G., Verweij, Paul E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852403/
https://ncbi.nlm.nih.gov/pubmed/20404915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010080
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