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The Identification and Biochemical Characterization of Drug-Like Compounds that Inhibit Botulinum Neurotoxin Serotype A Endopeptidase Activity
A robust, high throughput, two-tiered assay for screening small molecule inhibitors against botulinum neurotoxin serotype A was developed and employed to screen 16,544 compounds. Thirty-four compounds were identified as potent hits employing the first-tier assay. Subsequently, nine were confirmed as...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876331/ https://ncbi.nlm.nih.gov/pubmed/20003913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2009.11.017 |
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