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The Identification and Biochemical Characterization of Drug-Like Compounds that Inhibit Botulinum Neurotoxin Serotype A Endopeptidase Activity

A robust, high throughput, two-tiered assay for screening small molecule inhibitors against botulinum neurotoxin serotype A was developed and employed to screen 16,544 compounds. Thirty-four compounds were identified as potent hits employing the first-tier assay. Subsequently, nine were confirmed as...

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Detalhes bibliográficos
Main Authors: Cai, Shuowei, Lindo, Paul, Park, Jong-Beak, Vasa, Kruti, Singh, Bal Ram
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876331/
https://ncbi.nlm.nih.gov/pubmed/20003913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2009.11.017
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