Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na(V)1.7 produce distinct pain disorders

BACKGROUND: Two groups of gain-of-function mutations in sodium channel Na(V)1.7, which are expressed in dorsal root ganglion (DRG) neurons, produce two clinically-distinct pain syndromes - inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). IEM is characterized by intermitte...

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Detalhes bibliográficos
Main Authors: Cheng, Xiaoyang, Dib-Hajj, Sulayman D, Tyrrell, Lynda, Wright, Dowain A, Fischer, Tanya Z, Waxman, Stephen G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876140/
https://ncbi.nlm.nih.gov/pubmed/20429905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-24
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