Two Nedd4-binding Motifs Underlie Modulation of Sodium Channel Na(v)1.6 by p38 MAPK

Sodium channel Na(v)1.6 is essential for neuronal excitability in central and peripheral nervous systems. Loss-of-function mutations in Na(v)1.6 underlie motor disorders, with homozygous-null mutations causing juvenile lethality. Phosphorylation of Na(v)1.6 by the stress-induced p38 MAPK at a Pro-Gl...

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Detalhes bibliográficos
Main Authors: Gasser, Andreas, Cheng, Xiaoyang, Gilmore, Elaine S., Tyrrell, Lynda, Waxman, Stephen G., Dib-Hajj, Sulayman D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924020/
https://ncbi.nlm.nih.gov/pubmed/20530479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098681
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