Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function

Elevated Src kinase activity is linked to the progression of solid tumors, including head and neck squamous cell carcinoma (HNSCC). Src regulates HNSCC proliferation and tumor invasion, with the Src-targeted small molecule inhibitor saracatinib displaying potent anti-invasive effects in preclinical...

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Autors principals: Ammer, Amanda Gatesman, Kelley, Laura C., Hayes, Karen E., Evans, Jason V., Lopez-Skinner, Lesly Ann, Martin, Karen H., Frederick, Barbara, Rothschild, Brian L., Raben, David, Elvin, Paul, Green, Tim P., Weed, Scott A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875552/
https://ncbi.nlm.nih.gov/pubmed/20505783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/1948-5956.1000009
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