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Active Chromatin Marks Are Retained on X Chromosomes Lacking Gene or Repeat Silencing Despite XIST/Xist Expression in Somatic Cell Hybrids
BACKGROUND: X-chromosome inactivation occurs early in mammalian development and results in the inactive X chromosome acquiring numerous hallmarks of heterochromatin. While XIST is a key player in the inactivation process, the method of action of this ncRNA is yet to be determined. METHODOLOGY/PRINCI...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Public Library of Science
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875404/ https://ncbi.nlm.nih.gov/pubmed/20520737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010787 |
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