Inhibition of ABCB1 (MDR1) Expression by an siRNA Nanoparticulate Delivery System to Overcome Drug Resistance in Osteosarcoma

BACKGROUND: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients' average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (...

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Main Authors: Susa, Michiro, Iyer, Arun K., Ryu, Keinosuke, Choy, Edwin, Hornicek, Francis J., Mankin, Henry, Milane, Lara, Amiji, Mansoor M., Duan, Zhenfeng
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875382/
https://ncbi.nlm.nih.gov/pubmed/20520719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010764
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