Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance

BACKGROUND: Multi-drug resistance (MDR) remains a significant obstacle to successful chemotherapy treatment for osteosarcoma patients. One of the central causes of MDR is the overexpression of the membrane bound drug transporter protein P-glycoprotein (P-gp), which is the protein product of the MDR...

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Pubblicato in:Oncotarget
Autori principali: Liu, Tang, Li, Zhihong, Zhang, Qing, Bernstein, Karen De Amorim, Lozano-Calderon, Santiago, Choy, Edwin, Hornicek, Francis J., Duan, Zhenfeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347784/
https://ncbi.nlm.nih.gov/pubmed/27835872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13148
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