Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance

BACKGROUND: Multi-drug resistance (MDR) remains a significant obstacle to successful chemotherapy treatment for osteosarcoma patients. One of the central causes of MDR is the overexpression of the membrane bound drug transporter protein P-glycoprotein (P-gp), which is the protein product of the MDR...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Tang, Li, Zhihong, Zhang, Qing, Bernstein, Karen De Amorim, Lozano-Calderon, Santiago, Choy, Edwin, Hornicek, Francis J., Duan, Zhenfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347784/
https://ncbi.nlm.nih.gov/pubmed/27835872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13148
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados