Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma

The dismal prognosis of glioblastoma (GB) indicates the urgent need for new therapies for these tumors. Heat shock protein 90 (HSP90) inhibitors induce proteasome-mediated degradation of many oncogenic client proteins involved in all of the hallmark characteristics of cancer. Here, we explored the m...

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Main Authors: Gaspar, Nathalie, Sharp, Swee Y, Eccles, Suzanne A, Gowan, Sharon, Popov, Sergey, Jones, Chris, Pearson, Andrew, Vassal, Gilles, Workman, Paul
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875164/
https://ncbi.nlm.nih.gov/pubmed/20457619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0683
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